High-intensity interval training (HIIT) is a type of exercise characterized by the execution of intense movements for short periods, followed by intervals of low intensity exercise. In this way, NP-LLC is able to protect teas from oxidation and enhance the antioxidant effect of phenol present in GT, as demonstrated in a previous publication. Furthermore, the NP-LLC matrix increases the stability and durability of bioactive compounds. In addition, LC structures are found in animals, plants and bacteria, showing biomimetic characteristics that make NP-LLC an important strategy for incorporating bioactive substances. Systems based on nanoparticle lyotropic liquid crystal (NP-LLC) have attracted attention due to their ability to incorporate bioactive components in oil or water. The LC state is divided into thermotropic, dependent on temperature variation, and lyotropic, dependent on a solvent in addition to temperature. Liquid crystal (LC) is a state of matter between the crystalline solid and the isotropic liquid. Liposomes, proliposomes, microspheres, nanoparticles, polymers and liquid crystals are, among others, examples of drug delivery techniques. The systems have the ability to deliver an active substance more selectively to a specific site and they can improve the frequency of dosing, decrease variability in systemic drug concentrations, and reduce toxic metabolites. However, polyphenols from GT, when in infusion, are subject to oxidation after preparation, which may reduce their biological action.ĭrug delivery systems are techniques used to incorporate bioactive compounds. It is a potent natural antioxidant with anti-inflammatory, antimicrobial, anticarcinogenic, antihypertensive, neuroprotective, cholesterol-lowering and thermogenic properties. GT is rich in polyphenols, and catechins correspond to more than 70% of them epigallocatechin-3-gallate being the most prevalent catechin GT. sinensis, GT is the least handled, which preserves its characteristic color and nutrients. They are differentiated by the extraction and manufacturing process of the leaves and stems. Moreover, the effects of GT-NP-LLC itself on body mass and biochemical parameters are promising, suggesting NP-LLC could improve the bioavailability of GT.Ĭamellia sinensis is a plant responsible for three varieties of tea: green tea (GT), black tea and oolong tea. GT and GT-NP-LLC supplementation combined with HIIT presented higher muscle hypertrophy (25 and 21%, respectively), better physical conditioning, and reduced body weight gain rate compared to HIIT by itself. GT-NP-LLC and Ex reduced triglycerides compared to C. The percentages of body mass reduction were 11.3, 13.0, 10.0 and 11.0% for Ex, GT+Ex, GT-NP-LLC and GT-NP-LLC+Ex, respectively, compared to control. Body weight was significantly lower in all groups subjected to HIIT compared to C. Healthy male rats were randomized into six groups ( n = 6/group): Control (C), GT, GT-NP-LLC, Exercise (Ex), GT+Ex, GT-NP-LLC+Ex. Monoolein, GT in infusion and Poloxamer 407 were mixed to obtain nanoparticles of LLC (NP-LLC). Thus, this research aimed to compare the effects of GT and GT loaded in LLC in animals subjected to HIIT, considering hematological, biochemical and histological parameters, redox status, and body mass. High-intensity interval training (HIIT) is a workout modality that increases the production of reactive oxygen species (ROS). Lyotropic liquid crystals (LLCs) are nanostructured systems used to incorporate bioactive compounds. Green tea (GT) is a natural antioxidant, sensitive to oxidation after preparation.
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